Methandrostenolone Drug Profile

When it comes to enhancing performance and giving a new meaning to muscle mass, muscle function, and body strength, there is nothing better than Dianabol. A very anabolic and androgenic drug that provides little progestational activity, this legal anabolic steroid and performance enhancing drug is one of the most potent drugs to dramatically improve glycogenolysis, nitrogen storage, and protein synthesis levels.

Categorized as a Schedule III drug under the Anabolic Steroid Control Act of 1990, Dianabol (also known as Dbol, Methandrostenolone, and methandienone) is one of the most popular anabolic steroids and performance enhancing drugs. This anabolic compound has the unique ability to deactivate deactivates steroids to prevent them from further reactions with the body by minimizing SHBG (sex hormone binding globulin).

The chemical name of Dianabol is [17a-methyl-17b-hydroxy-1,4-androstadien-3-one] and its molecular formula is C20H28O2. It has an anabolic-androgenic ratio of 90-210:40-60 and can be detected over a period of six weeks. It has the molecular weight of 300.44 g/mol at the base.

Medically, this steroid is indicated globally by medical practitioners to treat health complications, including chronic adrenocortical insufficiency, thyrotoxicosis, interstitial-pituitary insufficiency, diabetic angiopathies (retinopathy and nephropathy), steroidal diabetes, and pituitary dwarfism and is even suggested during radiotherapy for laryngeal tumors. The 17α-methylation of the steroid helps it easily pass through the liver and this anabolic steroid has a profound effect on protein metabolism. Moreover, use of this steroid is associated with a normalizing effect on all functions of the body to promote physical and mental state and improving sleep patterns besides improvement of mood, self-esteem, appetite, and self-confidence enhancements. Multiple doses of it are required to be taken throughout the day since it has a short active life.

The recommended daily dose of this steroid for men is 25-50 mg per day when taken in oral form and 50-150 mg weekly when taken in an injectable form and is generally stacked with testosterone enanthate, Nandrolone, Anadrol, Proviron, testosterone propionate, Trenbolone acetate, and testosterone cypionate and post cycle therapy with antiestrogens such as Clomid and Nolvadex for restoring production of naturally-occurring testosterone and reduce or eliminate estrogenic side effects.

Use of this extremely potent performance improvement drug is not recommended for girls and women, especially those who may get pregnant while using the steroid or already pregnant or lactating and this drug is also not advised to children or those struggling with hypertension, high blood pressure, and prostate or breast cancer or suffering from testicular atrophy, testicular cancer, liver damage, kidney damage, stroke, high blood pressure, and respiratory problems. Abuse of Dianabol may lead to increased aggression, male pattern baldness, clitoral hypertrophy, oily skin bouts, and insomnia and lack of or contravention to medical advice can cause difficulty when urinating, edema (swelling), fever, or pain in the lower back (particularly in the kidney areas) and even high blood pressure and damage to kidneys

Benefits of Dianabol

Dianabol, also known as Dbol and Methandrostenolone, is considered by sportsmen and gym coaches as one of the best oral and injectable anabolic steroids when it comes to promoting muscle mass and body strength gains. This performance enhancing drug can be purchased in varying forms such as pills, creams, gels, injections, and capsules under names like Metandienone, Methandienone, Reforvit-b, Averbol, and Danabol.

Since Dianabol has an active life of three to eight hours, it is best used in small and divided doses at regular intervals throughout the day. Classified as a Schedule III drug as per the Anabolic Steroid Control Act of 1990, the anabolic steroid is medically recommended to treat health conditions required improved protein synthesis and even recommended to osteoporosis patients. It is also advised to HIV/AIDS patients who are suffering from muscle wasting or may be used during radiotherapy for laryngeal cancers.

This 17-α alkylated steroid is well-known for having a profound effect on protein metabolism and results in positive nitrogen balance that further translates into sense of well being improvements. In addition to that, Dbol use is also associated with unmatched androgenic and anabolic characteristics and this is one of the biggest reasons why the anabolic steroid is commonly made a part of mass building stacks. Use of this steroid for a period of eight to twelve weeks is linked to dramatic improvements in the context of muscle tissue, muscle function, glycogenolysis, nitrogen retention, protein synthesis, and muscle strength. This steroid also provides progestational activity and sportsmen on Dbol can expect weight gains of two to four pounds per week when used in a cycle of 6 weeks. Dianabol use is also associated with improvements in the levels of mood, self-esteem, appetite, and self-confidence and facilitating normalizing effect on all functions of the body to promote mental and physical state and improving sleep.

Among all the steroids available in the market today, Dianabol is one steroid whose popularity has neither diminished nor pulled down despite new entrants in the market. This is because apart from the obvious benefits it gives to its users; it also brings about many added gains to them. Although every steroid promises certain results, the best drug is one which also promises to keep its user away from the incidence of side effects. Dianabol offers all this and much more to its users. Let’s find out!

The most obvious benefits of Dianabol are good quality gains in muscle mass and size. Today most people seeking steroid use have this as their prime goal. Apart from bodybuilders who employ D-bol to achieve their muscle density, there are men, young and old, who with an intent to chisel their muscles, take this steroid. The fact that results met after the intake of D-bol are fast and effective makes it so sought after among its users. Thus, despite being one of the oldest steroids ever produced by mankind, Dianabol has still retained its demand around the globe.

 

Methandrostenolone Chemical and Molecular Data

PubChem CID: 6300
Molecular Formula: C20H28O2

Commomn Synonyms:
Methandienone

Metandienone

Molecular Weight:  300.4 g/mol

Methandrostenolone is an organic molecular entity.

URL: http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:6810
Chemical Entities of Biological Interest (ChEBI) is a database and ontology of molecular entities focused on ‘small’ chemical compounds, that is part of the Open Biomedical Ontologies effort. The term “molecular entity” refers to any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer, etc., identifiable as a separately distinguishable entity.

Common Methandrostenolone Trade Names

Averbol, Dianabol, Danabol, also known as metandienone (INN) or methandienone, is an orally-effective anabolic steroid originally developed in Germany and released in the US in the early 1960s by Ciba Specialty Chemicals. Methandrostenolone is a controlled substance in the United States and Western Europe, but remains popular among bodybuilders.

Consequently, it can be found on the United States black market. However, methandrostenolone is readily available without a prescription in countries such as Mexico (under the trade name Reforvit-b), and is also being manufactured in Asia and many East European countries.

From Human Metabolome Database (HMDB)
Source: Human Metabolome Database (HMDB)
Record Name: Metandienone
URL: http://www.hmdb.ca/metabolites/HMDB0041925

The Human Metabolome Database (HMDB) is a freely available electronic database containing detailed information about small molecule metabolites found in the human body.
A synthetic steroid with anabolic properties that are more pronounced than its androgenic effects. It has little progestational activity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1188)

Methandrostenolone IUPAC and Other Common Names

(8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13,17-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one

Molecular Formula HelpNew Window
C20H28O2

MeSH Entry Terms

Medical Subject Heading (MeSH) names or identifiers matching this PubChem Compound record. The matching between the MeSH and compound records is performed by name matching (i.e., identical common names).

Dianabol – Methandrostenolone Synonyms

Methandienone
Metandienone
METHANDROSTENOLONE
72-63-9
Dianabol
Metanabol
Metandienonum
Methandrolone
Metandienon
Nerobol
Metandrostenolon
Metandrostenolone
Metastenol
Nerobolettes

Protobolin
Anabolin
Andoredan
Danabol
Dianabole
Encephan
Naposim
Stenolon
Stenolone
Abirol
Crein
Dehydromethyltestosterone
Geabol
Anabolicum Medivet
Methylandrostenolone

Therapeutic Uses of Oral Anabolic Steroids

Reference: National Library of Medicine’s Medical Subject Headings online file (MeSH, 1999)

A two compartment, double-blind, randomized, parallel study was performed comparing methandrostenolone with placebo in the treatment of osteoporosis. The duration of the study was 24 mo.

Dependent parameters included total body calcium (TBCa), measured by neutron activation analysis: bone mineral content of the radius (BMC), measured by photon absorptiometry; and total body potassium (TBK), measured by total body counting.

A significant increase in TBK occurred in the treated group, primarily in the first 6 mo; thereafter the TBK remained fairly constant. No significant changes in bone mass occurred, except the 6 mo TBCa measurement increased by 11 grams for the methandrostenolone group and decreased by 6 grams for the placebo group (p = .05).

Other evidence also suggests that anabolic steroids may not produce sustained uncoupling of bone formation and bone resorption in osteoporosis. If methandrostenolone is capable of producing an increment in bone mass in osteoporosis, it was not readily observable with the sensitivity of the techniques employed in this study

PMID:7026971

Aloia JF et al; Metabolism 30 (11): 1076-9 (1981)

from HSDB

VETERINARY: orally, to increase nitrogen retention and increase serum protein values aiding in tissue repair and decrease healing time after surgery, burns, or skin grafts. Also in geriatric states, debilitation, and after chronic infections. As aid in calcium retention in senile, corticosteroid induced, or idiopathic osteoporosis.

Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 346

Drug Warnings and Possible Side Effects of Methandrostenolone

Use of anabolic steroids by athletes is not recommended. Objective evidence is conflicting and inconclusive as to whether these medications significantly increase athletic performance by increasing muscle strength.

Weight gains reported by athletes are due in part to fluid retention, which is a potentially hazardous side effect of anabolic steroid therapy.

The risk of other unwanted effects, such as testicular atrophy and suppression of spermatogenesis in males; menstrual disturbances and virilization, such as deepening of voice, development of acne, and unnatural growth of body hair in females; peliosis hepatis or other hepatotoxicity; and hepatic cancer outweigh any possible benefit received from anabolic steroids and make their use in athletes inappropriate.

Thomson.Micromedex. Drug Information for the Health Care Professional. 25th ed. Volume 1. Plus Updates. Content Reviewed by the United States Pharmacopeial Convention, Inc. Greenwood Village, CO. 2005., p. 140

Hepatocellular carcinoma has been associated rarely with long-term, high-dose anabolic steroid therapy. /Anabolic Steroids/

Thomson.Micromedex. Drug Information for the Health Care Professional. 25th ed. Volume 1. Plus Updates. Content Reviewed by the United States Pharmacopeial Convention, Inc. Greenwood Village, CO. 2005., p. 141

Hepatic neoplasms have been associated rarely with long-term, high-dose anabolic steroid therapy. /Anabolic Steroids/

Thomson.Micromedex. Drug Information for the Health Care Professional. 25th ed. Volume 1. Plus Updates. Content Reviewed by the United States Pharmacopeial Convention, Inc. Greenwood Village, CO. 2005., p. 141

FDA Pregnancy Category X. /CONTRAINDICATED IN PREGNANCY. Studies in animals and or humans, or investigational or post-marketing reports, have demonstrated positive evidence of fetal abnormalities or risk which clearly outweighs any possible benefit to the patient./

Thomson.Micromedex. Drug Information for the Health Care Professional. 25th ed. Volume 1. Plus Updates. Content Reviewed by the United States Pharmacopeial Convention, Inc. Greenwood Village, CO. 2005., p. 141

It is not known whether anabolic steroids are distributed into breast milk. Problems in humans have not been documented. Women who take anabolic steroids should not breast feed. /Anabolic Steroids/

Thomson.Micromedex. Drug Information for the Health Care Professional. 25th ed. Volume 1. Plus Updates. Content Reviewed by the United States Pharmacopeial Convention, Inc. Greenwood Village, CO. 2005., p. 141

Anabolic steroids should be used with caution in children and adolescents and only by specialists who are aware of their effects on bone maturation because of possible premature epiphyseal closure, precocious sexual development in males, and virilization in females. The epiphyseal maturation may be accelerated more rapidly than linear growth in children, and the effect may continue for 6 months after the medication has been discontinued. /Anabolic Steroids/

Thomson.Micromedex. Drug Information for the Health Care Professional. 25th ed. Volume 1. Plus Updates. Content Reviewed by the United States Pharmacopeial Convention, Inc. Greenwood Village, CO. 2005., p. 141

Treatment of geriatric male patients with anabolic steroids may cause increased risk of prostatic hyperplasia or prostatic carcinoma. In general, dose selection of an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal , or cardiac function, and of concomitant disease or other drug therapy. /Anabolic Steroids/

Thomson.Micromedex. Drug Information for the Health Care Professional. 25th ed. Volume 1. Plus Updates. Content Reviewed by the United States Pharmacopeial Convention, Inc. Greenwood Village, CO. 2005., p. 141

Except under special circumstances, /anabolic steroids/ should not be used when the following medical problems exist: breast cancer, disseminated, in females with active hypercalcemia; breast cancer in males severe hepatic function impairment; active or history of hypercalcemia (may be exacerbated or recurrence may result); nephrosis or nephrotic phase of nephritis; prostate cancer (tumor growth may be promoted). /Anabolic Steroids/

Thomson.Micromedex. Drug Information for the Health Care Professional. 25th ed. Volume 1. Plus Updates. Content Reviewed by the United States Pharmacopeial Convention, Inc. Greenwood Village, CO. 2005., p. 142

Virilism (acne or oily skin; enlarging clitoris; hoarseness or deepening of voice; menstrual irregularities; unnatural hair growth or loss) /has been reported/ in females only at an incidence more frequent Note: Enlarging clitoris, hoarseness or deepening of voice, and unnatural hair growth or loss usually are not reversible even after prompt discontinuance of therapy. The concurrent use of estrogens will not prevent virilization in females./Anabolic Steroids/

Thomson.Micromedex. Drug Information for the Health Care Professional. 25th ed. Volume 1. Plus Updates. Content Reviewed by the United States Pharmacopeial Convention, Inc. Greenwood Village, CO. 2005., p. 142

Virilism (acne; enlarging penis; increased frequency of erections; unnatural hair growth) /has been reported/ in prepubertal males only at an incidence more frequent. /Anabolic Steroids/

Thomson.Micromedex. Drug Information for the Health Care Professional. 25th ed. Volume 1. Plus Updates. Content Reviewed by the United States Pharmacopeial Convention, Inc. Greenwood Village, CO. 2005., p. 142

Bladder irritability (frequent urge to urinate); breast soreness; gynecomastia (enlargement of breasts), or priapism (frequent or continuing erections) have been reported in postpubertal males only at an incidence more frequent.

Thomson.Micromedex. Drug Information for the Health Care Professional. 25th ed. Volume 1. Plus Updates. Content Reviewed by the United States Pharmacopeial Convention, Inc. Greenwood Village, CO. 2005., p. 142

Adverse effects having an incidence less frequent in both females and males Anemia, iron deficiency (loss of appetite; sore tongue); edema (swelling of feet or lower legs; rapid weight gain); gastric irritation (nausea; vomiting); hepatic dysfunction (yellow eyes or skin); leukemia (bone pain), or suppression of clotting factors (unusual bleeding).

Thomson.Micromedex. Drug Information for the Health Care Professional. 25th ed. Volume 1. Plus Updates. Content Reviewed by the United States Pharmacopeial Convention, Inc. Greenwood Village, CO. 2005., p. 142

Hypercalcemia (mental depression; nausea; vomiting; unusual tiredness) /has been reported/ in females only at an incidence less frequent.

Thomson.Micromedex. Drug Information for the Health Care Professional. 25th ed. Volume 1. Plus Updates. Content Reviewed by the United States Pharmacopeial Convention, Inc. Greenwood Village, CO. 2005., p. 142

Unexplained darkening of skin /has been reported/ in prepubertal males only at an incidence less frequent.

Thomson.Micromedex. Drug Information for the Health Care Professional. 25th ed. Volume 1. Plus Updates. Content Reviewed by the United States Pharmacopeial Convention, Inc. Greenwood Village, CO. 2005., p. 142

Prostatic carcinoma or prostatic hyperplasia (difficult or frequent urination) has been reported in geriatric males only at an incidence less frequent.

Thomson.Micromedex. Drug Information for the Health Care Professional. 25th ed. Volume 1. Plus Updates. Content Reviewed by the United States Pharmacopeial Convention, Inc. Greenwood Village, CO. 2005., p. 142

Adverse effects having a rare incidence with prolonged therapy; hepatic necrosis (black, tarry stools; continuing feeling of discomfort; headache; continuing unpleasant breath odor; vomiting of blood); hepatocellular carcinoma (abdominal or stomach pain; unexplained weight loss), or peliosis hepatis (continuing loss of appetite; dark-colored urine; fever; hives; light-colored stools; nausea and vomiting; purple- or red-colored spots on body or inside the mouth or nose; sore throat).

Thomson.Micromedex. Drug Information for the Health Care Professional. 25th ed. Volume 1. Plus Updates. Content Reviewed by the United States Pharmacopeial Convention, Inc. Greenwood Village, CO. 2005., p. 142

In 6 bodybuilders taking methandrostenolone (up to 20 mg/day intermittent for a yr or more) plasma testosterone levels were low and lh levels reduced. Abnormal liver function tests seen in 3/6, and 1 had mild diabetes with high serum cholesterol triglycerides and uric acids.

Shephard RJ et al; Br J Sports Med 11(4): 170 (1977)Use of long term androgenic anabolic steroids suggest that they may be possible cause of hepatic angiosarcoma.

Falk H et al; Hepatic Angiosarcoma Associated With Androgenic Anabolic Steroids; Lancet 2(11): 1120 (1979)

Anabolic steroids are not recommended for use during pregnancy, since studies in animals have shown that anabolic steroids cause masculinization of the fetus. Risk-benefit must be carefully considered.

Thomson.Micromedex. Drug Information for the Health Care Professional. 25th ed. Volume 1. Plus Updates. Content Reviewed by the United States Pharmacopeial Convention, Inc. Greenwood Village, CO. 2005., p. 141

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